P62-plasmid Changes Tumor Microenvironment
- ✓
- Elenagen elevates expression of alpha-smooth muscle actin (alpha-SMA).
- ✓
- The higher the expression of stromal proteins, including alpha-SMA is, the lower the risk of a tumor is.
Evaluation of the intratumoral stromal content of alpha-sma
A) before
B) after p62 DNA treatment
- ✓
- Elenagen changes intratumoral extracellular matrix and elevates expression of collagen 3 (Col 3).
- ✓
- High level of Col3 in the tumor is associated with positive disease prognosis.
Evaluation of Col.I and Col 3 expression in tumor biopsies in tumor extracellular matrix
A) before
B) after p62 DNA treatment